LongevityMap Gene
Gene details
- HGNC symbol
- EIF4B
- Aliases
- EIF-4B; PRO1843
- Common name
- eukaryotic translation initiation factor 4B
- Description
- Cytogenetic Location
- 12q13.13
- UCSC Genome Browser
- View 12q13.13 on the UCSC genome browser
- OMIM
- 603928
- Ensembl
- ENSG00000063046
- UniProt/Swiss-Prot
- B4DRM3_HUMAN
- Entrez Gene
- 1975
- UniGene
- 648394
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
- Conclusions
- As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
- Indentifier
- EIF4B
- Reference