LongevityMap Gene
Gene details
- HGNC symbol
- CYP2B6
- Aliases
- CPB6; EFVM; IIB1; P450; CYP2B; CYP2B7; CYP2B7P; CYPIIB6
- Common name
- cytochrome P450 family 2 subfamily B member 6
- Description
- This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 19q13.2
- UCSC Genome Browser
- View 19q13.2 on the UCSC genome browser
- OMIM
- 123930
- Ensembl
- ENSG00000197408
- UniProt/Swiss-Prot
- CP2B6_HUMAN
- Entrez Gene
- 1555
- UniGene
- 1360
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- si:zfos-411a11.2
- Danio rerio
- cyp2y3
- Mus musculus
- Cyp2b9
- Mus musculus
- Cyp2b19
- Mus musculus
- Cyp2b10
- Mus musculus
- Cyp2b13
- Rattus norvegicus
- Cyp2b15
- Rattus norvegicus
- LOC108348266
- Rattus norvegicus
- LOC103691072
- Rattus norvegicus
- Cyp2b2
- Rattus norvegicus
- Cyp2b12
- Rattus norvegicus
- LOC103691092
- Rattus norvegicus
- LOC108348266
- Rattus norvegicus
- AC142154.2
- Rattus norvegicus
- Cyp2b3
- Rattus norvegicus
- Cyp2b21
In other databases
- GenDR gene expression
- A homolog of this gene for Mus musculus is present as Cyp2b13
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs2054675
- Reference