LongevityMap Gene
Gene details
- HGNC symbol
- CCL5
- Aliases
- SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta
- Common name
- C-C motif chemokine ligand 5
- Description
- This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
- Cytogenetic Location
- 17q12
- UCSC Genome Browser
- View 17q12 on the UCSC genome browser
- OMIM
- 187011
- Ensembl
- ENSG00000271503
- UniProt/Swiss-Prot
- CCL5_HUMAN
- Entrez Gene
- 6352
- UniGene
- 514821
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- GenAge microarray genes
- This gene is present as CCL5
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Spanish
- Study Design
- Three polymorphisms in inflammation-related genes RANTES and CCR5 were studied in 104 elderly and 110 controls
- Conclusions
- Only RANTES Int1.1T/C (rs2280789) was significantly different between elderly and controls. RANTES -403G allele (rs2107538) was less frequent in elderly males. RANTES -403A-Int1.1T haplotype was overrepresented in elderly males and RANTES -403G-Int1.1C was overrepresented in elderly females.
- Indentifier
- rs2107538
- Reference