LongevityMap Gene
Gene details
- HGNC symbol
- ATG13
- Aliases
- KIAA0652; PARATARG8
- Common name
- autophagy related 13
- Description
- The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016]
- Cytogenetic Location
- 11p11.2
- UCSC Genome Browser
- View 11p11.2 on the UCSC genome browser
- OMIM
- 615088
- Ensembl
- ENSG00000175224
- UniProt/Swiss-Prot
- A8K0S6_HUMAN
- Entrez Gene
- 9776
- UniGene
- 127403
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- atg-13
- Danio rerio
- atg13
- Drosophila melanogaster
- Atg13
- Mus musculus
- Atg13
- Rattus norvegicus
- Atg13
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
- Conclusions
- As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
- Indentifier
- ATG13
- Reference