LongevityMap Gene

Gene details

HGNC symbol: AKT1S1
Aliases: Lobe; PRAS40
Common name: AKT1 substrate 1
Description: AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008]
Cytogenetic Location: 19q13.33
UCSC Genome Browser: View 19q13.33 on the UCSC genome browser
OMIM: 610221
Ensembl: ENSG00000204673
UniProt/Swiss-Prot: A0A024QZF6_HUMAN
Entrez Gene: 84335
UniGene: 515542
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: akt1s1
Mus musculus: Akt1s1
Rattus norvegicus: Akt1s1

In other databases

CellAge

This gene is present as AKT1S1

Studies (1)

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

Dutch

Study Design

1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls

Conclusions

As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing

Indentifier

AKT1S1

Reference