LongevityMap Gene
Gene details
- HGNC symbol
- ACACA
- Aliases
- ACC; ACAC; ACC1; ACCA; ACACAD
- Common name
- acetyl-CoA carboxylase alpha
- Description
- Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 17q12
- UCSC Genome Browser
- View 17q12 on the UCSC genome browser
- OMIM
- 200350
- Ensembl
- ENSG00000278540
- UniProt/Swiss-Prot
- A0A024R0Y2_HUMAN
- Entrez Gene
- 31
- UniGene
- 160556
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- T28F3.5
- Danio rerio
- acaca
- Drosophila melanogaster
- ACC
- Mus musculus
- Acaca
- Rattus norvegicus
- Acaca
- Saccharomyces cerevisiae
- ACC1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs2302800
- Reference