LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- American (Caucasian)
- Study Design
- F2 20210 G/A SNP was examined in 2689 healthy Caucasians aged 17-39 years (n = 979; 505 males and 474 females), 40-59 years (n = 900; 526 males and 374 females), and 60-85 years (n = 810; 530 males and 280 females)
- Conclusions
- No statistically significant decrease in genotype or allele frequency was observed among carriers of F2
- Identifier
- 20210G/A
- In Other Studies (IDs)
- 38 65
- Cytogenetic Location
- 11p11.2
- UCSC Genome Browser
- View 11p11.2 on the UCSC genome browser
Gene details
- HGNC symbol
- F2
- Aliases
- PT; THPH1; RPRGL2
- Common name
- coagulation factor II, thrombin
- Description
- Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
- Other longevity studies of this gene
- 2
- OMIM
- 176930
- Ensembl
- ENSG00000180210
- UniProt/Swiss-Prot
- THRB_HUMAN
- Entrez Gene
- 2147
- UniGene
- 655207
- HapMap
- View on HapMap