LongevityMap variant group

Entry Details

Longevity Association: Significant
Population: Italian (Northern)
Study Design: Three SNPs in the SIRT3 gene were examined in 549 genomic DNA from Treviso Longeva study. A Cross-sectional analysis was carried out by comparing people over and under 85 years of age, followed by a longitudinal analysis considering mortality as the dependent variable.
Conclusions: Longitudinal analysis showed an association for rs4980329, rs11555236 in whole cohort and females (but cross-sectional analysis showed no association; see other entries from the same study). SIRT3 genetic variability might be relevant for the modulation of human longevity in the Italian population.

HGNC symbol: SIRT3
Aliases: SIR2L3
Common name: sirtuin 3
Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 24
OMIM: 604481
Ensembl: ENSG00000142082
UniProt/Swiss-Prot: SIR3_HUMAN
Entrez Gene: 23410
UniGene: 716456
HapMap: View on HapMap

GenAge model organism genes

GenAge human genes

GenDR gene manipulations

CellAge

Albani et al. (2014)