LongevityMap variant group
Entry Details
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. This result is consistent with their associations with physical functioning and suggests that the variability of genes in the pro-antioxidant pathway can influence survival through an effect on physical performances, at least in the analyzed cohort.
Variants (4)
1.
- Identifier
- rs11235972
- In Other Studies (IDs)
- 1334
- Cytogenetic Location
- 11q13.4
- UCSC Genome Browser
- View 11q13.4 on the UCSC genome browser
2.
- Identifier
- rs1685354
- In Other Studies (IDs)
- 2855
- Cytogenetic Location
- 11q13.4
- UCSC Genome Browser
- View 11q13.4 on the UCSC genome browser
3.
- Identifier
- rs3781907
- In Other Studies (IDs)
- 1337
- Cytogenetic Location
- 11q13.4
- UCSC Genome Browser
- View 11q13.4 on the UCSC genome browser
4.
- Identifier
- s647126
- Cytogenetic Location
- 11q13.4
- UCSC Genome Browser
- View 11q13.4 on the UCSC genome browser
Gene details
- HGNC symbol
- UCP3
- Aliases
- SLC25A9
- Common name
- uncoupling protein 3
- Description
- Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]
- Other longevity studies of this gene
- 9
- OMIM
- 602044
- Ensembl
- ENSG00000175564
- UniProt/Swiss-Prot
- A0A0S2Z4G5_HUMAN
- Entrez Gene
- 7352
- UniGene
- 101337
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- GenAge human genes
- This gene is present as UCP3