LongevityMap variant group
Entry Details
- Longevity Association
- Significant
- Population
- Korean
- Study Design
- 463 biomarkers in 176 diesase associated genes were examined in 137 long lived individuals (>90 y, 59.1% female, 96.73 ± 3.97 y) and 213 young controls (12-14 y, 39.4% female, 12.93 ± 0.80)
- Conclusions
- PAX4 was associated with longevity (P = 0.008) after correcting for multiple hypothesis testing
Variants (3)
1.
- Identifier
- rs327519
- Cytogenetic Location
- 7q32.1
- UCSC Genome Browser
- View 7q32.1 on the UCSC genome browser
2.
- Identifier
- rs712700
- Cytogenetic Location
- 7q32.1
- UCSC Genome Browser
- View 7q32.1 on the UCSC genome browser
3.
- Identifier
- rs327517
- Cytogenetic Location
- 7q32.1
- UCSC Genome Browser
- View 7q32.1 on the UCSC genome browser
Gene details
- HGNC symbol
- PAX4
- Aliases
- KPD; MODY9
- Common name
- paired box 4
- Description
- This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 2
- OMIM
- 167413
- Ensembl
- ENSG00000106331
- UniProt/Swiss-Prot
- PAX4_HUMAN
- Entrez Gene
- 5078
- UniGene
- 129706
- HapMap
- View on HapMap