LongevityMap variant group
Entry Details
- Longevity Association
- Significant
- Population
- Danish, German, Dutch
- Study Design
- 102 SNPs from 16 longevity candidate genes were examined in Danish. 1089 individuals (ages 92.2-93.8, mean age 93.2, 71.3 female) and 736 middle-aged controls (46-55 y, mean age 50.6, 49.6% female) were involved in this case-control study. Then the results were replicated in a German cohort of 1613 individuals (95-110 y, 73.2% female) and 1104 middle-aged controls (mean age 67.2, SD 4.07, 74.3% female). A 11 years study was introduced in Danish cohort to identify the SNPs associated with longevity, then the results were verified in Dutch longitudinal cohort.
- Conclusions
- Gene-based analysis showed a significant association of variations in HSPA14 with longevity
Variants (4)
1.
- Identifier
- rs12770830
- Cytogenetic Location
- 10p13
- UCSC Genome Browser
- View 10p13 on the UCSC genome browser
2.
- Identifier
- rs17268499
- Cytogenetic Location
- 10p13
- UCSC Genome Browser
- View 10p13 on the UCSC genome browser
3.
- Identifier
- rs7905174
- Cytogenetic Location
- 10p13
- UCSC Genome Browser
- View 10p13 on the UCSC genome browser
4.
- Identifier
- rs9787671
- Cytogenetic Location
- 10p13
- UCSC Genome Browser
- View 10p13 on the UCSC genome browser
Gene details
- HGNC symbol
- HSPA14
- Aliases
- HSP70-4; HSP70L1
- Common name
- heat shock protein family A (Hsp70) member 14
- Description
- Other longevity studies of this gene
- 3
- OMIM
- 610369
- Ensembl
- ENSG00000187522
- UniProt/Swiss-Prot
- B0YIZ1_HUMAN
- Entrez Gene
- 51182
- UniGene
- 534169
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- F44E5.4
- Caenorhabditis elegans
- F44E5.4
- Danio rerio
- hspa14
- Mus musculus
- Hspa14
- Rattus norvegicus
- Hspa14
- Saccharomyces cerevisiae
- SSA4
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as SSA4