LongevityMap variant group
Entry Details
- Longevity Association
- Significant
- Population
- Danish, German, Dutch
- Study Design
- 102 SNPs from 16 longevity candidate genes were examined in Danish. 1089 individuals (ages 92.2-93.8, mean age 93.2, 71.3 female) and 736 middle-aged controls (46-55 y, mean age 50.6, 49.6% female) were involved in this case-control study. Then the results were replicated in a German cohort of 1613 individuals (95-110 y, 73.2% female) and 1104 middle-aged controls (mean age 67.2, SD 4.07, 74.3% female). A 11 years study was introduced in Danish cohort to identify the SNPs associated with longevity, then the results were verified in Dutch longitudinal cohort.
- Conclusions
- The minor allele frequency of rs769449 in APOE was significantly decreased in the oldest-old. Haplotype case–control comparisons identified an haplotype with rs405509, rs440446 and rs769449 associated with longevity. Gene-based analysis confirmed the significant association of variations in APOE with longevity. The association of rs769449 was confirmed in the German population.
Variants (3)
1.
- Identifier
- rs405509
- Cytogenetic Location
- 19q13.32
- UCSC Genome Browser
- View 19q13.32 on the UCSC genome browser
2.
- Identifier
- rs440446
- Cytogenetic Location
- 19q13.32
- UCSC Genome Browser
- View 19q13.32 on the UCSC genome browser
3.
- Identifier
- rs769449
- Cytogenetic Location
- 19q13.32
- UCSC Genome Browser
- View 19q13.32 on the UCSC genome browser
Gene details
- HGNC symbol
- APOE
- Aliases
- AD2; LPG; APO-E; ApoE4; LDLCQ5
- Common name
- apolipoprotein E
- Description
- The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
- Other longevity studies of this gene
- 30
- OMIM
- 107741
- Ensembl
- ENSG00000130203
- UniProt/Swiss-Prot
- A0A0S2Z3D5_HUMAN
- Entrez Gene
- 348
- UniGene
- 654439
- HapMap
- View on HapMap