LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- English (Caucasian) and Nigerian
- Study Design
- 638G/A (Arg 213 to His) SNP was examined in Caucasian (n=293; 12-99 years old) and African (Nigerian, n=52) populations
- Conclusions
- A significant age-related difference in genotype was observed within Caucasian population, with increasing incidence of SULT1A11 homozygosity and decreasing incidence of SULT1A12 homozygosity with increasing age
- Identifier
- 638G/A
- Cytogenetic Location
- 16p11.2
- UCSC Genome Browser
- View 16p11.2 on the UCSC genome browser
Gene details
- HGNC symbol
- SULT1A1
- Aliases
- PST; STP; STP1; P-PST; ST1A1; ST1A3; TSPST1; HAST1/HAST2
- Common name
- sulfotransferase family 1A member 1
- Description
- Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 2
- OMIM
- 171150
- Ensembl
- ENSG00000196502
- UniProt/Swiss-Prot
- ST1A1_HUMAN
- Entrez Gene
- 6817
- UniGene
- 567342
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- GenDR gene expression
- A homolog of this gene for Mus musculus is present as Sult1a1