LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: American of Japanese origin
Study Design: Nested case-control design was used in 213 longevity phenotype subjects (80-93 y, 85.6±3.1) and 402 controls (71-79 y, 74.6±2.1) to identify the association between genetic variation in insulin/IGF-1 signaling genes and longevity
Conclusions: No association was found between genetic variation in any of the tested genes and longevity in American men of Japanese ancestry

HGNC symbol: EXO1
Aliases: HEX1; hExoI
Common name: exonuclease 1
Description: This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 20
OMIM: 606063
Ensembl: ENSG00000174371
UniProt/Swiss-Prot: A8K5H6_HUMAN
Entrez Gene: 9156
UniGene: 498248
HapMap: View on HapMap

GenAge model organism genes

CellAge gene expression

Morris et al. (2014)