LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Chinese (Han)
- Study Design
- 485 longevity subjects and 392 younger individuals were analyzed for the promoter region of the IGF-1 gene . By sequencing about 2.5 kb (kilo base pairs) upstream the transcription start site of exon 1 of the IGF-1 gene in 30 individuals from both groups respectively, 3 previously described SNPs (-439T/A (rs2288377), -541T/C (rs5742612) and -1246C/T (rs35767)) were acquired. Association was examined between these 3 SNPs and longevity by comparing the distribution of genotypes, alleles, and haplotypes in both the longevity and control groups.
- Conclusions
- None of the 3 SNP variants were found to be associated with longevity in the Han Chinese population.
- HGNC symbol
- IGF1
- Aliases
- MGF; IGFI; IGF-I
- Common name
- insulin like growth factor 1
- Description
- The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
- Other longevity studies of this gene
- 9
- OMIM
- 147440
- Ensembl
- ENSG00000017427
- UniProt/Swiss-Prot
- IGF1_HUMAN
- Entrez Gene
- 3479
- UniGene
- 160562
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- igf1
- Mus musculus
- Igf1
- Rattus norvegicus
- Igf1
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Igf1
- GenAge human genes
- This gene is present as IGF1
- GenAge microarray genes
- This gene is present as IGF1
Xie et al. (2008)
Other variants which are also part of this study
