LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: Danish
Study Design: Intron 8 insertion 311 polymorphism was examined in 187 Danish centenarians, and 201 healthy Danish blood donors, aged 20-64 years (mean age 42 years)
Conclusions: No significant differences relative to longevity were found

HGNC symbol: PLAT
Aliases: TPA; T-PA
Common name: plasminogen activator, tissue type
Description: This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
OMIM: 173370
Ensembl: ENSG00000104368
UniProt/Swiss-Prot: B4DN26_HUMAN
Entrez Gene: 5327
UniGene: 491582
HapMap: View on HapMap

CellAge gene expression

Bladbjerg et al. (1999)