LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study using 1,471 genotyped participants from the Framingham Heart Study, of which 1,173 individuals had known lifespans, plus 517 individuals from the Offspring cohort for validating connections between longevity and genetic variants
- Conclusions
- A total of 27 SNPs, including in CDH4, SVEP1, CACNA1C, CARS, STK24, C7orf50, PARVG, NCAM2, PPP2R2C, NLRC5, BTBD9, RAC2, TGFA, KIAA0649, ABCC4, CLSTN2, FAM19A5 and RUNX3, were identified at the intersection of various statistical procedures
- Identifier
- rs10937739
- Cytogenetic Location
- 4p16.1
- UCSC Genome Browser
- View 4p16.1 on the UCSC genome browser
Gene details
- HGNC symbol
- PPP2R2C
- Aliases
- PR52; PR55G; IMYPNO; IMYPNO1; B55gamma; B55-GAMMA
- Common name
- protein phosphatase 2 regulatory subunit Bgamma
- Description
- The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- OMIM
- 605997
- Ensembl
- ENSG00000074211
- UniProt/Swiss-Prot
- 2ABG_HUMAN
- Entrez Gene
- 5522
- UniGene
- 479069
- HapMap
- View on HapMap