LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study using 1,471 genotyped participants from the Framingham Heart Study, of which 1,173 individuals had known lifespans, plus 517 individuals from the Offspring cohort for validating connections between longevity and genetic variants
- Conclusions
- A total of 27 SNPs were identified at the intersection of various statistical procedures
- Identifier
- rs9876781
- Cytogenetic Location
- 3p21.31
- UCSC Genome Browser
- View 3p21.31 on the UCSC genome browser
Gene details
- HGNC symbol
- ATRIP
- Aliases
- Common name
- ATR interacting protein
- Description
- This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
- OMIM
- 606605
- Ensembl
- ENSG00000164053
- UniProt/Swiss-Prot
- A0A024R2U4_HUMAN
- Entrez Gene
- 84126
- UniGene
- 694840
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- atrip
- Mus musculus
- Atrip
- Rattus norvegicus
- LOC100911807
- Rattus norvegicus
- Atrip