LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Danish, German, Dutch
- Study Design
- 102 SNPs from 16 longevity candidate genes were examined in Danish. 1089 individuals (ages 92.2-93.8, mean age 93.2, 71.3 female) and 736 middle-aged controls (46-55 y, mean age 50.6, 49.6% female) were involved in this case-control study. Then the results were replicated in a German cohort of 1613 individuals (95-110 y, 73.2% female) and 1104 middle-aged controls (mean age 67.2, SD 4.07, 74.3% female). A 11 years study was introduced in Danish cohort to identify the SNPs associated with longevity, then the results were verified in Dutch longitudinal cohort.
- Conclusions
- Gene-based analysis showed a significant association of variations in SIRT6 with longevity, though this seemed to reflect the association of a single SNP (rs107251)
- Identifier
- rs107251
- Cytogenetic Location
- 19p13.3
- UCSC Genome Browser
- View 19p13.3 on the UCSC genome browser
Gene details
- HGNC symbol
- SIRT6
- Aliases
- SIR2L6
- Common name
- sirtuin 6
- Description
- This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
- OMIM
- 606211
- Ensembl
- ENSG00000077463
- UniProt/Swiss-Prot
- B4DDV3_HUMAN
- Entrez Gene
- 51548
- UniGene
- 423756
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- sir-2.4
- Danio rerio
- SIRT6
- Drosophila melanogaster
- Sirt6
- Mus musculus
- Sirt6
- Rattus norvegicus
- Sirt6