LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- Alleles in candidate pathways (GH/IGF1 signaling, DNA damage signaling and repair and pro/antioxidants) were investigated for association with longevity in 1089 oldest-old (age 92-93) and 736 middle-aged Danes
- Conclusions
- Six SNPs (in TNXRD1, XDH, GHRL, MLH1, H2AFX, XRCC5) were associated with mortality in late life after correction for multiple hypothesis testing. No replications were observed in German and Dutch populations.
- Identifier
- rs207444
- In Other Studies (IDs)
- 2581
- Cytogenetic Location
- 2p23.1
- UCSC Genome Browser
- View 2p23.1 on the UCSC genome browser
Gene details
- HGNC symbol
- XDH
- Aliases
- XO; XOR; XAN1
- Common name
- xanthine dehydrogenase
- Description
- Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014]
- Other longevity studies of this gene
- 23
- OMIM
- 607633
- Ensembl
- ENSG00000158125
- UniProt/Swiss-Prot
- XDH_HUMAN
- Entrez Gene
- 7498
- UniGene
- 250
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- F55B11.1
- Caenorhabditis elegans
- gad-3
- Caenorhabditis elegans
- F15E6.6
- Danio rerio
- xdh
- Drosophila melanogaster
- AOX4
- Drosophila melanogaster
- ry
- Drosophila melanogaster
- AOX1
- Drosophila melanogaster
- AOX2
- Drosophila melanogaster
- AOX3
- Mus musculus
- Xdh
- Rattus norvegicus
- Xdh