LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- Alleles in candidate pathways (GH/IGF1 signaling, DNA damage signaling and repair and pro/antioxidants) were investigated for association with longevity in 1089 oldest-old (age 92-93) and 736 middle-aged Danes
- Conclusions
- Eleven SNPs (in GSR, KL, GHRHR, INS, GHSR, IGF2R, RAD52, WRN, RAD23B, POLB and NTLH1) were associated with longevity after correction for multiple hypothesis testing. No replications were observed in German and Dutch populations.
- Identifier
- rs1002149
- In Other Studies (IDs)
- 3148
- Cytogenetic Location
- 8p12
- UCSC Genome Browser
- View 8p12 on the UCSC genome browser
Gene details
- HGNC symbol
- GSR
- Aliases
- HEL-75; HEL-S-122m
- Common name
- glutathione-disulfide reductase
- Description
- This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]
- Other longevity studies of this gene
- 8
- OMIM
- 138300
- Ensembl
- ENSG00000104687
- UniProt/Swiss-Prot
- GSHR_HUMAN
- Entrez Gene
- 2936
- UniGene
- 271510
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- gsr-1
- Danio rerio
- gsr
- Mus musculus
- Gsr
- Rattus norvegicus
- Gsr
- Saccharomyces cerevisiae
- GLR1
- Schizosaccharomyces pombe
- pgr1
In other databases
- GenAge human genes
- This gene is present as GSR