LongevityMap variant

Entry Details

Longevity Association
Non-significant
Population
Chinese (Han)
Study Design
Association study in 493 elderly Han Chinese individuals (females = 94; males = 90) and 425 young individuals (controls)
Conclusions
No association between the microsatellite polymorphism and longevity was found. However, there were more male persons with 18/21 genotype in elderly group than that in control group (11.11 vs. 5.45%, p = 0.011), though the difference was not significant when corrected for multiple testing.
Identifier
IGF1
In Other Studies (IDs)
179 232
Cytogenetic Location
12q23.2
UCSC Genome Browser
View 12q23.2 on the UCSC genome browser

Gene details

HGNC symbol
IGF1
Aliases
MGF; IGFI; IGF-I 
Common name
insulin like growth factor 1 
Description
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
Other longevity studies of this gene
9
OMIM
147440
Ensembl
ENSG00000017427
UniProt/Swiss-Prot
IGF1_HUMAN
Entrez Gene
3479
UniGene
160562
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
igf1
Mus musculus
Igf1
Rattus norvegicus
Igf1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Igf1
GenAge human genes
  • This gene is present as IGF1
GenAge microarray genes
  • This gene is present as IGF1

References

Xie et al. (2010)

Other variants which are also part of this study