LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: American of Japanese origin
Study Design: 81 tagSNPs that provided virtually complete coverage of key mTOR genes complex genes MTOR, RPTOR, and RICTOR, as well as RPS6KA1, were tested in 814 males (440 aged 95 years and older, 374 controls) for association with longevity and health span phenotypes.
Conclusions: No association was found between genotypes and longevity or aging-related biologic, clinical or functional phenoypes after mutiple test correction.

HGNC symbol: RPTOR
Aliases: KOG1; Mip1
Common name: regulatory associated protein of MTOR complex 1
Description: This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Other longevity studies of this gene: 63
OMIM: 607130
Ensembl: ENSG00000141564
UniProt/Swiss-Prot: Q6DKI0_HUMAN
Entrez Gene: 57521
UniGene: 133044
HapMap: View on HapMap

GenAge model organism genes

CellAge

Morris et al. (2015)