LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: German
Study Design: 19 SNPs were examined in 1612 long-lived individuals (centenarians and nonagenarians) and 1104 younger controls as well as a subgroup of 748 centenarians from 1612 LLIs and 1104 younger controls.
Conclusions: No association was detected between the tested SNPs and the longevity phenotype, in the entire long-lived sample set nor in the centenarian subgroup analysis. There was no considerable influence of sequence variation in the SOD genes on human longevity in Germans.

HGNC symbol: SOD1
Aliases: ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer
Common name: superoxide dismutase 1
Description: The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 7
OMIM: 147450
Ensembl: ENSG00000142168
UniProt/Swiss-Prot: SODC_HUMAN
Entrez Gene: 6647
UniGene: 443914
HapMap: View on HapMap

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Gentschew et al. (2013)