LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Ashkenazi Jewish
- Study Design
- 205 centenarians (141 females, median age = 97 years and 64 males, median age = 97 years), their offspring (n = 145 total, 80 females, median age = 69 years and 65 males median age = 68 years), and 288 controls (167 females, median age = 74 years and 121 males, median age = 75 years) were examined for the association between genotype and longevity
- Conclusions
- A U-shape pattern of MTP CC genotype frequency with aging was observed. The CC was a buffered-deleterious genotype in the case group. In the control group without longevity genes, CC genotype included poorer survivorship.
- Identifier
- rs2542052
- In Other Studies (IDs)
- 213
- Cytogenetic Location
- 11q23.3
- UCSC Genome Browser
- View 11q23.3 on the UCSC genome browser
Gene details
- HGNC symbol
- APOC3
- Aliases
- HALP2; APOCIII
- Common name
- apolipoprotein C3
- Description
- Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 7
- OMIM
- 107720
- Ensembl
- ENSG00000110245
- UniProt/Swiss-Prot
- A3KPE2_HUMAN
- Entrez Gene
- 345
- UniGene
- 73849
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- GenAge human genes
- This gene is present as APOC3