LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- European and American (Caucasian)
- Study Design
- The allelic distribution of APOE isoforms E2, E3, and E4 were assessed among 10,623 participants
- Conclusions
- APOE alleles were associated with human longevity. There was a significant decrease in the frequency of E4 with increasing age (P = 0.0001), as well as a significantly increased frequency of E3 (P = 0.001). E2 showed little variation with age.
- Identifier
- rs429358
- In Other Studies (IDs)
- 328 779 902
- Cytogenetic Location
- 19q13.32
- UCSC Genome Browser
- View 19q13.32 on the UCSC genome browser
Gene details
- HGNC symbol
- APOE
- Aliases
- AD2; LPG; APO-E; ApoE4; LDLCQ5
- Common name
- apolipoprotein E
- Description
- The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
- Other longevity studies of this gene
- 30
- OMIM
- 107741
- Ensembl
- ENSG00000130203
- UniProt/Swiss-Prot
- A0A0S2Z3D5_HUMAN
- Entrez Gene
- 348
- UniGene
- 654439
- HapMap
- View on HapMap