- Symbol
- inaE
- Name
- inactivation no afterpotential E
- Organism
- Drosophila melanogaster (AnAge)
- Observations
- Fly mutants (EP-element insertion), exhibiting up-regulation of DAGL, display extended lifespan (mean is 72% higher) and enhanced oxidative stress response. Complementarily, mutants exhibiting down-regulation of DAGL have a shortened lifespan (mean is 50% lower) and reduced oxidative stress resistance. Additionally, transgenic overexpression of DAGL results in increased mean lifespan (up to 41%).
- % change in avg or median lifespan
- Mean lifespan is 73% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Danio rerio
- dagla
- Homo sapiens
- DAGLA
- Mus musculus
- Dagla
- Rattus norvegicus
- Dagla
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (32343)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for inaE (Drosophila melanogaster)