- Symbol
- fkh
- Name
- fork head
- Organism
- Drosophila melanogaster (AnAge)
- Observations
- Moderate adult-specific upregulation of fkh in flies increased median survival up to 14%. However, strong fkh induction led to short-lived flies. Gut specific expression of fkh improves gut barrier function in aged flies and increases the expression of nutrient transporters.
- % change in avg or median lifespan
- Median lifespan is 14% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as pha-4
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as pha-4
- CellAge
- A homolog of this gene for Homo sapiens is present as FOXA1
- Caenorhabditis elegans
- pha-4
- Danio rerio
- foxa1
- Danio rerio
- foxa2
- Danio rerio
- foxa
- Danio rerio
- foxa3
- Homo sapiens
- FOXA2
- Homo sapiens
- FOXA3
- Homo sapiens
- FOXA1
- Mus musculus
- Foxa3
- Mus musculus
- Foxa1
- Mus musculus
- Foxa2
- Rattus norvegicus
- Foxa1
- Rattus norvegicus
- Foxa2
- Rattus norvegicus
- Foxa3
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (43383)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for fkh (Drosophila melanogaster)