- Symbol
- alpha-Man-I
- Aliases
- alpha-Man-l; CG17809; CG18799; CG32682; CG32684; CG4227
- Name
- Alpha Mannosidase I
- Organism
- Drosophila melanogaster (AnAge)
- Observations
- Mutant flies showed enhanced resistance to paraquat and starvation and a 60% increase in mean lifespan for both sexes. After outcrossing, the mutant showed, under normal conditions, an increase in mean lifespan of 22% for females and 38% for males . The increase in maximum lifespan was 15%. RNAi knock-downs resulted in a 39% increase in mean lifespan.
- % change in max lifespan
- Maximum lifespan is 15% higher.
- % change in avg or median lifespan
- Average male lifespan is 38% higher; Average female lifespan is 22% higher; Average lifespan is 39% higher for RNAi knock-downs.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference, Mutations
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as D2030.1
- A homolog of this gene for Saccharomyces cerevisiae is present as MNS1
- GenAge microarray genes
- A homolog of this gene for Homo sapiens is present as MAN1A1
- Caenorhabditis elegans
- mans-1
- Caenorhabditis elegans
- mans-2
- Danio rerio
- man1a1
- Danio rerio
- si:ch73-373m9.1
- Danio rerio
- man1a2
- Homo sapiens
- MAN1A1
- Homo sapiens
- MAN1C1
- Homo sapiens
- MAN1A2
- Mus musculus
- Man1c1
- Mus musculus
- Man1a2
- Mus musculus
- Man1a
- Rattus norvegicus
- Man1a2
- Rattus norvegicus
- Man1a1
- Rattus norvegicus
- Man1c1
- Saccharomyces cerevisiae
- MNS1
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (31957)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for alpha-Man-I (Drosophila melanogaster)