- Symbol
- Trxr-1
- Aliases
- 2151; anon-WO03040301.185; anon-WO03040301.187; CG215
- Name
- Thioredoxin reductase-1
- Organism
- Drosophila melanogaster (AnAge)
- Known functions and activities
- Redox regulation and oxidative defence
- Observations
- Overexpression of glutathione reductase (GSR) in transgenic flies resulted in increased lifespan and oxidative stress resistance, but only under hyperoxia. Glutathione reductase is now recognized to be performed by thioredoxin reductase-1 (Trxr-1) since Drosophila do not have a GSR gene.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Danio rerio
- TXNRD2
- Danio rerio
- txnrd2
- Homo sapiens
- TXNRD2
- Mus musculus
- Txnrd2
- Rattus norvegicus
- Txnrd2
- Saccharomyces cerevisiae
- GLR1
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (31760)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Trxr-1 (Drosophila melanogaster)