Drosophila melanogasterGenAge entry for Trx-2 (Drosophila melanogaster)

Gene information (ID: 685)

Symbol
Trx-2
Aliases
31884; anon-WO0118547.188; CG31884; CG3864; DmelTrx-2;
Name
thioredoxin-2
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
Thioredoxin

Potential relevance to longevity and/or ageing

Observations
Mutants have a 25% reduction in maximum lifespan and exhibited lower tolerance to oxidative stress while animals carrying multiple copies of Trx-2 exhibited higher tolerance.
% change in max lifespan
Maximum lifespan is 25% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as trx-1
    • A homolog of this gene for Saccharomyces cerevisiae is present as TRX1
    GenDR gene manipulations
    • A homolog of this gene for Caenorhabditis elegans is present as trx-1

    Homologs in other organisms

    Caenorhabditis elegans
    trx-1
    Saccharomyces cerevisiae
    TRX2
    Saccharomyces cerevisiae
    TRX1
    Schizosaccharomyces pombe
    trx1

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (34281)
    Homologues
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    UniProt
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    Internet
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