- Symbol
- Top3alpha
- Name
- Topoisomerase 3alpha
- Organism
- Drosophila melanogaster (AnAge)
- Observations
- Mutant M1L flies, which lack mitochondrial Top3alpha, show decreased median and maximum lifespan when compared to wild type flies. The flies demonstrated a premature ageing phenotype, had mobility defects, and exhibited elevated levels of mitochondrial degeneration.
- % change in max lifespan
- Maximum lifespan is 25% lower.
- % change in avg or median lifespan
- Median lifespan is 20% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutation
- Longevity Category
- Pro-Longevity
- Primary reference
-
- CellAge
- A homolog of this gene for Homo sapiens is present as TOP3A
- Caenorhabditis elegans
- top-3
- Danio rerio
- top3a
- Homo sapiens
- TOP3A
- Mus musculus
- Top3a
- Rattus norvegicus
- Top3a
- Saccharomyces cerevisiae
- TOP3
- Schizosaccharomyces pombe
- top3
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (35236)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Top3alpha (Drosophila melanogaster)