GenAge entry for Sirt6 (Drosophila melanogaster)
Gene information (ID: 611)
- Symbol
- Sirt6
- Aliases
- CG6284; D.mel4; Dmel\CG6284; dmSRT408; dSIRT6
- Name
- CG6284-PB
- Organism
- Drosophila melanogaster (AnAge)
- Known functions and activities
- NAD(+)-dependent histone deacetylase that silences gene expression
Potential relevance to longevity and/or ageing
- Observations
- Decreased expression by RNA interference caused lethality during development. Silencing in neurons shortened mean lifespan by 20%.
- % change in avg or median lifespan
- Average lifespan is 20% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
Homologs in other organisms
No homologs found
External links
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (41254)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar