- Symbol
- Sirt4
- Name
- Sirtuin 4
- Organism
- Drosophila melanogaster (AnAge)
- Observations
- Flies overexpressing Sirt4 demonstrated a 20% increase in median lifespan compared to controls. Specific expression of Sirt4 in the fat body resulted in increased lifespan in males and females. Sirt4 knockout flies are short-lived compared to controls and had a 28% decrease in median lifespan in females and a 17% decrease in median lifespan in males.
- % change in avg or median lifespan
- Median lifespan is 20% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
- A homolog of this gene for Saccharomyces cerevisiae is present as HST1
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
- A homolog of this gene for Saccharomyces cerevisiae is present as HST1
- Caenorhabditis elegans
- sir-2.2
- Caenorhabditis elegans
- sir-2.3
- Danio rerio
- sirt4
- Homo sapiens
- SIRT4
- Mus musculus
- Sirt4
- Rattus norvegicus
- Sirt4
- Saccharomyces cerevisiae
- HST1
- Saccharomyces cerevisiae
- SIR2
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (31480)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Sirt4 (Drosophila melanogaster)