Drosophila melanogasterGenAge entry for SdhC (Drosophila melanogaster)

Gene information (ID: 594)

Symbol
SdhC
Aliases
BcDNA:RH04289; CG6666; Dmel\CG6666; sdhC
Name
succinate dehydrogenase, cytochrome b556 subunit
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
Succinate dehydrogenase

Potential relevance to longevity and/or ageing

Observations
Mutants expressing a dominant negative form of sdhC in the nervous system had a 22% reduced mean lifespan and signs of oxidative stress induction.
% change in avg or median lifespan
Average lifespan is 22% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Dominant negative mutation
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as mev-1
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as SDHC

    Homologs in other organisms

    Caenorhabditis elegans
    mev-1
    Danio rerio
    sdhc
    Homo sapiens
    SDHC
    Mus musculus
    Sdhc
    Rattus norvegicus
    Sdhc
    Schizosaccharomyces pombe
    sdh3

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (41340)
    Homologues
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    UniProt
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    Internet
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