Drosophila melanogasterGenAge entry for Prx5 (Drosophila melanogaster)

Gene information (ID: 875)

Symbol
Prx5
Aliases
CG; 32920; CG; 7217; CG32920; CG7217; Dmel\CG7217; dprx5;
Name
Peroxiredoxin 5
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression caused an increase in mean and median lifespan under normal conditions. A small increase in maximum lifespan was also observed. In contrast, the dprx5 (-/-) null flies were comparatively more susceptible to oxidative stress, had higher incidence of apoptosis, and a shortened mean life span. For the dprx5 (-/-) null flies there were no significant differences in maximum age (10% survival).
% change in avg or median lifespan
Average lifespan is up to 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    prdx5
    Homo sapiens
    PRDX5
    Mus musculus
    Prdx5
    Rattus norvegicus
    Prdx5
    Saccharomyces cerevisiae
    AHP1
    Schizosaccharomyces pombe
    pmp20

    External links

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    Entrez Gene
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