- Symbol
- Nf1
- Aliases
- CG8318; Dmel\CG8318; dNF1; Nf-1; NF-1; nf1; NF1
- Name
- Neurofibromin 1
- Organism
- Drosophila melanogaster (AnAge)
- Known functions and activities
- Tumor supressor
- Observations
- NF1 mutants had a shortened lifespan and exhibited increased vulnerability to heat and oxidative stress as well as reduced mitochondrial respiration and elevated ROS production. Overexpression of NF1 increased mitochondrial respiration and reduced ROS production. It increased mean lifespan by 49% in males and 68% in females and maximum lifespan by 38% in males and 52% in females. It also improved reproductive fitness.
- % change in max lifespan
- Maximum male lifespan is 38% higher; Maximum female lifespan is 52% higher.
- % change in avg or median lifespan
- Average male lifespan is 49% higher; Average female lifespan is 69% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- CellAge
- A homolog of this gene for Homo sapiens is present as NF1
- Danio rerio
- nf1b
- Danio rerio
- nf1a
- Homo sapiens
- NF1
- Mus musculus
- Nf1
- Rattus norvegicus
- Nf1
- Saccharomyces cerevisiae
- IRA2
- Saccharomyces cerevisiae
- IRA1
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (43149)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Nf1 (Drosophila melanogaster)