- Symbol
- Men
- Aliases
- anon-WO0118547.278; CG10120; Dmel\CG10120; MDH; Mdh-NA
- Name
- Malic enzyme
- Organism
- Drosophila melanogaster (AnAge)
- Observations
- Ubiquitous and constitutive overexpression of the malic enzyme (Men), during the larval period, extends the maximum lifespan of fruit flies by 24% in males and by 39% in females. Contrastly, Men overexpression in the adult abdominal fat body does not affect lifespan.
- % change in max lifespan
- Male maximum lifespan is 24% higher. Female maximum lifespan is 39% higher.
- % change in avg or median lifespan
- Median lifespan is approximately 45% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenDR gene manipulations
- This gene is present as Men
- CellAge
- A homolog of this gene for Homo sapiens is present as ME1
- A homolog of this gene for Homo sapiens is present as ME2
- Caenorhabditis elegans
- men-1
- Danio rerio
- me2
- Danio rerio
- CABZ01025780.1
- Danio rerio
- me1
- Danio rerio
- me3
- Homo sapiens
- ME2
- Homo sapiens
- ME1
- Homo sapiens
- ME3
- Mus musculus
- Me1
- Mus musculus
- Me3
- Mus musculus
- Me2
- Rattus norvegicus
- Me2
- Rattus norvegicus
- Me1
- Rattus norvegicus
- Me3
- Saccharomyces cerevisiae
- MAE1
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (47173)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Men (Drosophila melanogaster)