- Symbol
- Jafrac1
- Aliases
- 1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1; dPrx; I; Dpx-47
- Name
- Thioredoxin peroxidase 1
- Organism
- Drosophila melanogaster (AnAge)
- Observations
- Neuronal overexpression of Jafrac1 significantly increased both mean and maximal lifespan, while neuronal knockdown of Jafrac1 , as well as the loss-of-function mutation, caused a reduction in lifespan of up to 30%.
- % change in max lifespan
- Average male lifespan is 29% higher; Average female lifespan is 26% higher; Maximum male lifespan is up to 26% higher; Maximum female lifespan is aprox. 22% higher.
- % change in avg or median lifespan
- Average male lifespan is 29% higher; Average female lifespan is 26% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Overexpression caused a 15% mean lifespan extension.
- % change in avg or median lifespan
- Average lifespan is 15% higher
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as prdx-2
- A homolog of this gene for Mus musculus is present as Prdx1
- A homolog of this gene for Saccharomyces cerevisiae is present as TSA1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as PRDX1
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as TSA1
- Caenorhabditis elegans
- prdx-2
- Danio rerio
- prdx1
- Danio rerio
- prdx2
- Homo sapiens
- PRDX1
- Homo sapiens
- PRDX2
- Mus musculus
- Prdx1
- Mus musculus
- Gm5225
- Mus musculus
- Prdx2
- Rattus norvegicus
- Prdx1
- Rattus norvegicus
- Prdx2
- Rattus norvegicus
- AABR07012795.1
- Saccharomyces cerevisiae
- TSA1
- Saccharomyces cerevisiae
- TSA2
- Schizosaccharomyces pombe
- tpx1
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (53578)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Jafrac1 (Drosophila melanogaster)