- Symbol
- Indy
- Aliases
- anon-EST:fe3A7; anon-WO0172774.70; BEST:LP01220; CG39
- Name
- I'm not dead yet protein
- Organism
- Drosophila melanogaster (AnAge)
- Known functions and activities
- Sodium-dependent citrate transporter
- Observations
- No effects of Indy on lifespan were observed after controlling for genetic background via backcrossing and Wolbachia infection.
- Lifespan Effect
- Noeffect
- Longevity Category
- Not Recorded
- Primary reference
-
- Observations
- Flies heterozygotic for a disruption have extended mean (87-92%) lifespan and maximum lifespan (45%). Homozygotes for the disruption show only a 10-20% increase in mean lifespan.
- % change in max lifespan
- Maximum lifespan is 45% higher.
- % change in avg or median lifespan
- Average lifespan is 87-92% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Knockout
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Reduction of Indy leads to a significant lifespan extension (26% male and 11% female).
- % change in avg or median lifespan
- Average female lifespan is 11% higher; Average male lifespan is 26% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutations
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as nac-2
- A homolog of this gene for Mus musculus is present as Slc13a1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as SLC13A1
- GenDR gene manipulations
- This gene is present as Indy
- LongevityMap
- A homolog of this gene for Homo sapiens is present as SLC13A2
- CellAge
- A homolog of this gene for Homo sapiens is present as SLC13A3
- Caenorhabditis elegans
- B0285.6
- Caenorhabditis elegans
- nac-2
- Danio rerio
- slc13a3
- Danio rerio
- slc13a2
- Danio rerio
- slc13a4
- Danio rerio
- slc13a5a
- Danio rerio
- slc13a1
- Danio rerio
- slc13a5b
- Homo sapiens
- SLC13A2
- Homo sapiens
- SLC13A3
- Homo sapiens
- SLC13A5
- Homo sapiens
- SLC13A1
- Homo sapiens
- SLC13A4
- Mus musculus
- Slc13a3
- Mus musculus
- Slc13a5
- Mus musculus
- Slc13a1
- Mus musculus
- Slc13a2
- Mus musculus
- Slc13a4
- Rattus norvegicus
- Slc13a5
- Rattus norvegicus
- Slc13a4
- Rattus norvegicus
- Slc13a3
- Rattus norvegicus
- Slc13a2
- Rattus norvegicus
- Slc13a1
- Schizosaccharomyces pombe
- SPBC3B8.04c
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (40049)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Indy (Drosophila melanogaster)