GenAge entry for Ilp6 (Drosophila melanogaster)
Gene information (ID: 1756)
- Symbol
- Ilp6
- Aliases
- CG14049; dilp; Dilp; DILP; Dilp; 6; dilp-6; dilp6; dILP6; D
- Name
- Insulin-like peptide 6
- Organism
- Drosophila melanogaster (AnAge)
Potential relevance to longevity and/or ageing
- Observations
- Conditional expression of dilp6 abdominal fat body extended lifespan in females maintained on a low-yeast diet but not on high-yeast diet. Conditional expression in head fat body modestly increased lifespan in females upon high-yeast diet but decreased it upon low-yeast diet. No detectable effect was seen for males on any diet. Conditional expression with ubiquitous drivers and ubiquitous RNAi resulted in shortened lifespan. Overexpression by a conditional pan-neuronal driver or fat body RNAi have no effect on lifespan.
- % change in avg or median lifespan
- Lifespan is up to 15.6% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
Homologs in other organisms
No homologs found
External links
- FlyBase
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- Ensembl
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- Entrez Gene
- View on Entrez Gene database (31220)
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar