Drosophila melanogasterGenAge entry for Gpdh (Drosophila melanogaster)

Gene information (ID: 2152)

Symbol
Gpdh
Name
Glycerol 3 phosphate dehydrogenase
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
A mutation that decreased Gpdh activity (59.6% of the wildtype) in flies increased lifespan by 20%. This difference in lifespan was also observed between mutant and wild type flies subjected to dietary restriction.
% change in avg or median lifespan
Mean lifespan is 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Caenorhabditis elegans
    gpdh-2
    Caenorhabditis elegans
    gpdh-1
    Danio rerio
    gpd1l
    Danio rerio
    gpd1a
    Danio rerio
    gpd1b
    Danio rerio
    gpd1c
    Homo sapiens
    GPD1L
    Homo sapiens
    GPD1
    Mus musculus
    Gpd1
    Mus musculus
    Gpd1l
    Rattus norvegicus
    Gpd1
    Rattus norvegicus
    Gpd1l
    Saccharomyces cerevisiae
    GPD1
    Saccharomyces cerevisiae
    GPD2

    External links

    FlyBase
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    Entrez Gene
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    Homologues
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    UniProt
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    Internet
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