- Symbol
- Gclc
- Aliases
- 2259; CG2259; Dmel\CG2259; DmGCLC; DmGCS; DmGCSh; GCL; GC
- Name
- Glutamate-cysteine ligase catalytic subunit
- Organism
- Drosophila melanogaster (AnAge)
- Known functions and activities
- Catalyzes the formation of glutathione
- Observations
- Overexpression extended mean and maximum lifespan by up to 50%.
- % change in max lifespan
- Maximal lifespan is up to 50% higher.
- % change in avg or median lifespan
- Average lifespan is up to 50% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as GCLC
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as GSH1
- LongevityMap
- A homolog of this gene for Homo sapiens is present as GCLC
- Caenorhabditis elegans
- gcs-1
- Danio rerio
- gclc
- Homo sapiens
- GCLC
- Mus musculus
- Gclc
- Rattus norvegicus
- Gclc
- Saccharomyces cerevisiae
- GSH1
- Schizosaccharomyces pombe
- gcs1
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (53581)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Gclc (Drosophila melanogaster)