GenAge entry for Gadd45 (Drosophila melanogaster)
Gene information (ID: 849)
- Symbol
- Gadd45
- Aliases
- BcDNA:RH70774; CG11086; D-GADD45; Dmel\CG11086; GADD45
- Name
- CG11086 gene product from transcript CG11086-RA
- Organism
- Drosophila melanogaster (AnAge)
Potential relevance to longevity and/or ageing
- Observations
- Overexpression of the D-GADD45 gene in the nervous system leads to a significantly increase of Drosophila lifespan without a decrease in fecundity and locomotor activity. The lifespan extension effect is more pronounced in males than in females. In addition an increase in maximum life span was detected.
- % change in max lifespan
- Maximum male lifespan is up to 59% higher; Maximum female lifespan is up to 50% higher.
- % change in avg or median lifespan
- Median male lifespan is up to 77% higher; Median female lifespan is up to 46% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
Homologs in other organisms
No homologs found
External links
- FlyBase
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- Ensembl
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- Entrez Gene
- View on Entrez Gene database (35646)
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar