- Symbol
- 14-3-3epsilon
- Aliases
- 14-3-3; 14-3-3; epsilon; 14-3-3-e; 14-3-3-epsilon; 14-3
- Name
- CG31196 gene product from transcript CG31196-RA
- Organism
- Drosophila melanogaster (AnAge)
- Observations
- Loss of 14-3-3e results in increased stress-induced apoptosis, growth repression and extended lifespan of flies, in a dFoxO dependent manner. Increased expression of 14-3-3e also reverts FoxO-induced growth defects. No effect on lifespan was observed when overexpressing 14-3-3e in adipose tissue, suggesting that endogenous FoxO activity in this tissue is low under normal conditions.
- % change in avg or median lifespan
- Average male lifespan is up to 25% higher; Average female lifespan is up to 49% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutations
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as BMH1
- A homolog of this gene for Saccharomyces cerevisiae is present as BMH2
- Danio rerio
- ywhae2
- Danio rerio
- ywhae1
- Homo sapiens
- YWHAE
- Mus musculus
- Ywhae
- Rattus norvegicus
- Ywhae
- Saccharomyces cerevisiae
- BMH1
- Saccharomyces cerevisiae
- BMH2
- Schizosaccharomyces pombe
- rad25
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (42186)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for 14-3-3epsilon (Drosophila melanogaster)