GenDR Dietary Restriction Gene Manipulation: Rpd3
Gene Information (Entrez Gene ID: 38565)
- Symbol
- Rpd3
- Aliases
- CG7471 dHDAC-1 dHDAC1 DHDAC1 Dmel\CG7471 dmHDA401 DmHDAC1 drpd3 dRpd3 dRPD3 DRpd3 E(var)3-64BC HDAC HDAC-1 hdac1 Hdac1 HDAC1 l(3)04556 l(3)64Cc rpd3 RPD3 Rpd3/HDAC rpd[3] Su(var)3-26 Su(var)326 Su(var)328
- Name
- Histone deacetylase Rpd3
- Organism
- Drosophila melanogaster (AnAge)
- Entrez Gene ID
- 38565
Potential relevance to dietary restriction and ageing
- Observations
-
Males heterozygous for hypomorphic or null mutation of Rpd3 have a lifespan extension of 33% and 41 - 47%, respectively. Females heterozygous for a hypomorphic allele have a 52% increase in lifespan, but females carrying a null mutation have only modest increase in maximum lifespan (but not median lifespan). Longevity increases to the same extent in wild-type under low-calorie diet and rpd3 mutants fed normal diet. DR fails to further increase lifespan of rpd3 mutants. DR leads to a moderate but significant down-regulation of Rpd3, analogous to decrease obtained in heterozygotes carrying rpd3 mutation. rpd3 mutants fed normal food and wild-type fed low-calorie increase Sir2 expression two-fold [202].
- References
-
In other databases
- GenAge model organism genes
- GenAge human genes
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as RPD3
- CellAge
Homologs
- Caenorhabditis elegans
- hda-1
- Caenorhabditis elegans
- hda-3
- Danio rerio
- hdac1
- Homo sapiens
- HDAC1
- Homo sapiens
- HDAC2
- Mus musculus
- Hdac1
- Mus musculus
- Hdac2
- Mus musculus
- Gm10093
- Rattus norvegicus
- Hdac2
- Rattus norvegicus
- Hdac1l
- Rattus norvegicus
- Hdac1
- Saccharomyces cerevisiae
- RPD3
- Schizosaccharomyces pombe
- clr6
External links
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 38565
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar