GenDR Dietary Restriction Gene Manipulation: PKH2
Gene Information (Entrez Gene ID: 854053)
- Symbol
- PKH2
- Name
- Pkb-activating Kinase Homolog 2
- Organism
- Saccharomyces cerevisiae (AnAge)
- Entrez Gene ID
- 854053
Potential relevance to dietary restriction and ageing
- Observations
-
PKH2 deletion increases replicative lifespan by 20% in the alpha strain and by 15% in the a strain [2504]. Deletion of PKH2 increases chronological lifespan by 29% [2632] to 34% [2593]. PKH2 mutation extends both replicative and chronological lifespan as well as cancels out DR-induced replicative and chronological lifespan extension [2581]. Mean and maximum replicative lifespan under ad libitum is extended by 38 and 69%, respectively.
- References
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In other databases
- GenAge model organism genes
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as PDPK1
- LongevityMap
- A homolog of this gene for Homo sapiens is present as PDPK1
- CellAge
- A homolog of this gene for Homo sapiens is present as PDPK1
Homologs
- Caenorhabditis elegans
- pdk-1
- Caenorhabditis elegans
- W04B5.5
- Caenorhabditis elegans
- Y106G6A.1
- Danio rerio
- pdpk1b
- Danio rerio
- pdpk1a
- Drosophila melanogaster
- Pdk1
- Drosophila melanogaster
- png
- Homo sapiens
- PDPK1
- Mus musculus
- Pdpk1
- Rattus norvegicus
- Pdpk1
- Schizosaccharomyces pombe
- ppk21
External links
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- ID 854053
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar