Saccharomyces cerevisiae GenDR Dietary Restriction Gene Manipulation: PKH2

Gene Information (Entrez Gene ID: 854053)

Symbol
PKH2
Name
Pkb-activating Kinase Homolog 2
Organism
Saccharomyces cerevisiae (AnAge)
Entrez Gene ID
854053

Potential relevance to dietary restriction and ageing

Observations

PKH2 deletion increases replicative lifespan by 20% in the alpha strain and by 15% in the a strain [2504]. Deletion of PKH2 increases chronological lifespan by 29% [2632] to 34% [2593]. PKH2 mutation extends both replicative and chronological lifespan as well as cancels out DR-induced replicative and chronological lifespan extension [2581]. Mean and maximum replicative lifespan under ad libitum is extended by 38 and 69%, respectively.

References

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as pdk-1
    • This gene is present as PKH2
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as PDPK1
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as PDPK1
    CellAge
    • A homolog of this gene for Homo sapiens is present as PDPK1

    Homologs

    Caenorhabditis elegans
    pdk-1
    Caenorhabditis elegans
    W04B5.5
    Caenorhabditis elegans
    Y106G6A.1
    Danio rerio
    pdpk1b
    Danio rerio
    pdpk1a
    Drosophila melanogaster
    Pdk1
    Drosophila melanogaster
    png
    Homo sapiens
    PDPK1
    Mus musculus
    Pdpk1
    Rattus norvegicus
    Pdpk1
    Schizosaccharomyces pombe
    ppk21

    External links

    Saccharomyces Genome Database
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    Ensembl
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    Entrez Gene
    ID 854053
    Homologues
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    UniProt
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    Internet
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