Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: daf-16

Gene Information (Entrez Gene ID: 172981)

Symbol
daf-16
Name
Abnormal DAuer Formation DAF-16, fork head-related transcription factor (daf-16)
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
172981

Potential relevance to dietary restriction and ageing

Observations

daf-16 is required for lifespan extension by mutation of daf-2 or age-1 [239]. In one experiment, daf-16 mutation suppressed lifespan extension by DR [2494]. Another study found that DR does not stimulate DAF-16 translocation to the nucleus, but daf-16 mutation cancels out the ability of DR to extend lifespan and to delay the decline in locomotor activity [2564]. In another study, DR by bacterial dilution extended lifespan of daf-16 mutants [2360]. daf-16 mutation decreases lifespan under ad lib, but fails to prevent bacterial dilution DR to further extend lifespan [2565]. Intermittent fasting-induced lifespan-extension is significantly diminished in null mutants of daf-16, suggesting daf-16 partially mediates intermittent fasting-induced longevity [2566]. daf-16 mutation cancels out the lifespan extension effect of solid DR and peptone dilution, regardless of the concentration of bacteria or peptones. Bacterial dilution DR significantly extends lifespan of daf-16 mutants, but to a lesser extent than that of wild-type. eat-2 mutation extends the lifespan of daf-16 mutants to the same extent than that of wild-type [2568]. Another study found that daf-16 RNAi completely blocks the lifespan extension by daf-2 mutation, but only partially by bacterial dilution DR [2569].

References

    In other databases

    GenAge model organism genes
    • This gene is present as daf-16
    • A homolog of this gene for Drosophila melanogaster is present as foxo
    • A homolog of this gene for Saccharomyces cerevisiae is present as HCM1
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as FOXO1
    • A homolog of this gene for Homo sapiens is present as FOXO3
    • A homolog of this gene for Homo sapiens is present as FOXO4
    GenDR gene manipulations
    • A homolog of this gene for Drosophila melanogaster is present as foxo
    • A homolog of this gene for Mus musculus is present as Foxo3
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as FOXO1
    • A homolog of this gene for Homo sapiens is present as FOXO3
    • A homolog of this gene for Homo sapiens is present as FOXO4
    CellAge
    • A homolog of this gene for Homo sapiens is present as FOXO1
    • A homolog of this gene for Homo sapiens is present as FOXO3
    • A homolog of this gene for Homo sapiens is present as FOXO4

    Homologs

    Danio rerio
    foxo4
    Danio rerio
    si:dkey-11f5.5
    Danio rerio
    si:ch211-206a7.2
    Danio rerio
    foxo1b
    Danio rerio
    foxo1a
    Danio rerio
    foxo3a
    Danio rerio
    foxo3b
    Drosophila melanogaster
    foxo
    Homo sapiens
    FOXO3
    Homo sapiens
    FOXO1
    Homo sapiens
    FOXO4
    Homo sapiens
    FOXO6
    Mus musculus
    Foxo6
    Mus musculus
    Foxo4
    Mus musculus
    Foxo3
    Mus musculus
    Foxo1
    Rattus norvegicus
    Foxo4
    Rattus norvegicus
    Foxo3
    Rattus norvegicus
    Foxo1
    Rattus norvegicus
    Foxo6
    Saccharomyces cerevisiae
    HCM1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 172981
    Homologues
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    UniProt
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    Internet
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