Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: age-1

Gene Information (Entrez Gene ID: 174762)

Symbol
age-1
Name
AGEing alteration 1
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
174762

Potential relevance to dietary restriction and ageing

Observations

Recessive knockout mutants of age-1 have a 40-65% increase in mean lifespan and a 65-110% increase in maximum lifespan [2237] [1518]. age-1(mg44) zygotic null mutants have a mean (99%) and maximum (117%) lifespan extension [2441]. age-1 mutation significantly extends lifespan under ad lib, but only slightly under solid DR [2494].

References

    In other databases

    GenAge model organism genes
    • This gene is present as age-1
    • A homolog of this gene for Saccharomyces cerevisiae is present as VPS34
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as PIK3CG

    Homologs

    Danio rerio
    si:rp71-17i16.5
    Danio rerio
    pik3cg
    Homo sapiens
    PIK3CG
    Mus musculus
    Pik3cg
    Rattus norvegicus
    Pik3cg
    Saccharomyces cerevisiae
    VPS34

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 174762
    Homologues
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    UniProt
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    Internet
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