Cell Senescence Entries for SNAI1
- Cell Types
- Prostate cancer
- Cell Lines
- LNCaP, PC-3
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Emadi Baygi et al. (2010) Snail regulates cell survival and inhibits cellular senescence in human metastatic prostate cancer cell lines. Cell Biol Toxicol 26(6)553-67 (PubMed)
SNAI1 Gene Information
- HGNC symbol
- SNAI1
- Aliases
- SLUGH2; SNA; SNAH; SNAIL; SNAIL1
- Common name
- snail family transcriptional repressor 1
- Entrez Id
- 6615
- Description
- The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008].
SNAI1 Ontologies
- Gene Ontology
-
Process: GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:6357; regulation of transcription by RNA polymerase II
GO:30335; positive regulation of cell migration
GO:10718; positive regulation of epithelial to mesenchymal transition
GO:3180; aortic valve morphogenesis
GO:1649; osteoblast differentiation
GO:3198; epithelial to mesenchymal transition involved in endocardial cushion formation
GO:10957; negative regulation of vitamin D biosynthetic process
GO:43518; negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:61314; Notch signaling involved in heart development
And 15 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5829; cytosol
GO:1650; fibrillar center
GO:5721; pericentric heterochromatin
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:5515; protein binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3700; DNA-binding transcription factor activity
GO:1990837; sequence-specific double-stranded DNA binding
GO:70888; E-box binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:19900; kinase binding
GO:43565; sequence-specific DNA binding
And 1 more GO terms
Homologs of SNAI1 in Model Organisms
- Danio rerio
- snai1b
- Danio rerio
- snai1a
- Drosophila melanogaster
- sna
- Drosophila melanogaster
- wor
- Drosophila melanogaster
- esg
- Mus musculus
- Snai1
- Rattus norvegicus
- Snai1
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as esg
External links
- OMIM
- 604238
- Ensembl
- ENSG00000124216
- Entrez Gene
- 6615
- UniGene
- 48029
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SNAI1
- GeneCards
- SNAI1